सार
मूंगफली (अरचिस हाइपोगिया) एग्लूटीनिन (पीएनए) का व्यापक रूप से ट्यूमर मार्कर के रूप में उपयोग किया जाता है क्योंकि यह कैंसर विशिष्ट टी एंटीजन (गैल्बेटा1–>3गैलएनएसी-) को दृढ़ता से पहचानता है, लेकिन इसके सियालेटेड संस्करण को नहीं। हालाँकि, Galbeta1–>4GlcNAc (LacNAc) के प्रति एक अतिरिक्त विशिष्टता, जो ट्यूमर विशिष्ट नहीं है, को PNA के लिए जिम्मेदार ठहराया गया था। लेक्टिन हिस्टोकेमिकल परिणामों की सही व्याख्या के लिए हमने प्राकृतिक रूप से पाए जाने वाले या अर्ध-सिंथेटिक ग्लाइकोप्रोटीन, मैट्रिक्स-इमोबिलाइज्ड गैलेक्टोसाइड्स और लेक्टिन-बाइंडिंग टिशू ग्लाइकोप्रोटीन का उपयोग करके पीएनए चीनी विशिष्टता की जांच की, बजाय मोनो- या डिसैकराइड को लिगैंड के रूप में। घुलनशील ग्लाइकोकोनजुगेट्स के डॉट-ब्लॉट्स, ट्रांसफर ब्लॉट्स या पॉलीस्टाइन प्लेट कोटिंग्स को पीएनए के हॉर्स-मूली पेरोक्सीडेज (एचआरपी) संयुग्म और ज्ञात विशिष्टता के अन्य व्याख्यान के साथ जांचा गया था। पीएनए-बाध्यकारी ग्लाइकोप्रोटीन के संशोधन, ओ-लिंक्ड ऑलिगोसेकेराइड्स के चयनात्मक निष्कासन और ग्लाइकोसिडेस के साथ उपचार सहित पता चला कि गैल्बेटा1–>4GlcNAc (LacNAc) अप्रभावी था, जबकि टर्मिनल अल्फा-लिंक्ड गैलेक्टोज (TAG) के साथ-साथ उजागर टी एंटीजन (Galbeta1–>3 GalNAc-) चीनी के रूप में उत्कृष्ट था। पीएनए द्वारा उनकी मान्यता के लिए ग्लाइकोप्रोटीन में मात्रा। स्थिर होने पर, पीएनए बाइंडिंग में मेलिबियोज लैक्टोज से बेहतर था। TAG-विशिष्ट मानव सीरम एंटी-अल्फा-गैलेक्टोसाइड एंटीबॉडी का उपयोग करके परिणामों की पुष्टि की गई।
अन्य नोट
लेक्टिंस ग्लाइकोकोनजुगेट्स के साथ अवक्षेपित होते हैं और ऑलिगोसेकेराइड्स को समान चीनी रचनाओं जैसे गैलेक्टोज, मैनोज या ग्लूकोज के साथ पहचानने या अलग करने के लिए उपयोगी होते हैं।
Arachis hypogaea (PNA, मूंगफली एग्लूटीनिन), 110kD, लगभग 27kD प्रत्येक के चार समान सबयूनिट्स से बना है, गैलेक्टोज-विशिष्ट है, जिसमें मजबूत एंटी-टी-एंटीजन गतिविधि है। टी-एंटीजन कई ग्लाइकोकोनजुगेट्स जैसे एम और एन रक्त समूहों, गैंग्लियोसाइड्स, और कई अन्य घुलनशील और झिल्ली से जुड़े ग्लाइकोप्रोटीन और ग्लाइकोलिपिड्स में मौजूद है। पीएनए सामान्य मानव एरिथ्रोसाइट्स को एकत्रित नहीं करता है, लेकिन दृढ़ता से न्यूरोमिनिडेस-उपचारित लाल रक्त कोशिकाओं को एग्लूटीनेट करता है। Ca++ की उपस्थिति रिसेप्टर्स के लिए PNA के बंधन को बढ़ा सकती है। एशियालो जीएम1 गैंग्लियोसाइड को पीएनए के लिए एक प्रमुख कोशिका सतह रिसेप्टर भी माना जाता है। पीएनए संक्रमणकालीन म्यूकोसा विकृतियों के लिए सामान्य और ट्यूमर ऊतक निर्धारण में उपयोगी है।
Biotin Conjugated Arachis hypogaea Lectin (Peanut) -PNA- |
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| BA-2301-1 | EY Laboratories | 1 mg | Ask for price |
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Description: Biotin Conjugated Arachis hypogaea Lectin (Peanut) -PNA-, 1mg Product volume may vary.
With the exception of Diagnostic Microbiology Products all biochemicals described are for research use only. The biochemical reagents are not designed for use in therapeutic or diagnostic applications. We are unable to ship to individuals. Please place all orders through an established firm or institution. Nothing disclosed is to be construed as a recommendation to use our products in violation of any patents. All research products are offered without warranty or guarantee, since the ultimate condition of use and the variability in material handling are beyond our control. |
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Biotin Conjugated Arachis hypogaea Lectin (Peanut) -PNA- |
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| BA-2301-2 | EY Laboratories | 2 mg | Ask for price |
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Description: Biotin Conjugated Arachis hypogaea Lectin (Peanut) -PNA-, 2mg Product volume may vary.
With the exception of Diagnostic Microbiology Products all biochemicals described are for research use only. The biochemical reagents are not designed for use in therapeutic or diagnostic applications. We are unable to ship to individuals. Please place all orders through an established firm or institution. Nothing disclosed is to be construed as a recommendation to use our products in violation of any patents. All research products are offered without warranty or guarantee, since the ultimate condition of use and the variability in material handling are beyond our control. |
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Biotin Conjugated Arachis hypogaea Lectin (Peanut) -PNA- |
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| BA-2301-5 | EY Laboratories | 5 mg | Ask for price |
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Description: Biotin Conjugated Arachis hypogaea Lectin (Peanut) -PNA-, 5mg Product volume may vary.
With the exception of Diagnostic Microbiology Products all biochemicals described are for research use only. The biochemical reagents are not designed for use in therapeutic or diagnostic applications. We are unable to ship to individuals. Please place all orders through an established firm or institution. Nothing disclosed is to be construed as a recommendation to use our products in violation of any patents. All research products are offered without warranty or guarantee, since the ultimate condition of use and the variability in material handling are beyond our control. |
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Ferritin Conjugated Arachis hypogaea Lectin (Peanut) -PNA- |
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| I-2301-1 | EY Laboratories | 1 mg | Ask for price |
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Description: Ferritin Conjugated Arachis hypogaea Lectin (Peanut) -PNA-, 1mg Product volume may vary.
With the exception of Diagnostic Microbiology Products all biochemicals described are for research use only. The biochemical reagents are not designed for use in therapeutic or diagnostic applications. We are unable to ship to individuals. Please place all orders through an established firm or institution. Nothing disclosed is to be construed as a recommendation to use our products in violation of any patents. All research products are offered without warranty or guarantee, since the ultimate condition of use and the variability in material handling are beyond our control. |
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Texas Red Conjugated Arachis hypogaea Lectin (Peanut) -PNA- |
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| T-2301-2 | EY Laboratories | 2 mg | Ask for price |
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Description: Texas Red Conjugated Arachis hypogaea Lectin (Peanut) -PNA-, 2mg Product volume may vary.
With the exception of Diagnostic Microbiology Products all biochemicals described are for research use only. The biochemical reagents are not designed for use in therapeutic or diagnostic applications. We are unable to ship to individuals. Please place all orders through an established firm or institution. Nothing disclosed is to be construed as a recommendation to use our products in violation of any patents. All research products are offered without warranty or guarantee, since the ultimate condition of use and the variability in material handling are beyond our control. |
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Dylight 549 Conjugated Arachis hypogaea Lectin (Peanut) -PNA- |
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| DY549-2301-1 | EY Laboratories | 1 mg | Ask for price |
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Description: Dylight 549 Conjugated Arachis hypogaea Lectin (Peanut) -PNA-, 1mg |
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Alkaline Phosphatase Conjugated Arachis hypogaea Lectin (Peanut) -PNA- |
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| LA-2301-1 | EY Laboratories | 1 mg | Ask for price |
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Description: Alkaline Phosphatase Conjugated Arachis hypogaea Lectin (Peanut) -PNA-, 1mg With the exception of Diagnostic Microbiology Products all biochemicals described are for research use only. The biochemical reagents are not designed for use in therapeutic or diagnostic applications. We are unable to ship to individuals. Please place all orders through an established firm or institution. Nothing disclosed is to be construed as a recommendation to use our products in violation of any patents. All research products are offered without warranty or guarantee, since the ultimate condition of use and the variability in material handling are beyond our control. |
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Colloidal Gold Conjugated Arachis hypogaea Lectin (Peanut) -PNA-, 5nm |
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| GP-2301-5 | EY Laboratories | 1 mL | Ask for price |
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Description: Colloidal Gold Conjugated Arachis hypogaea Lectin (Peanut) -PNA-, 5nm With the exception of Diagnostic Microbiology Products all biochemicals described are for research use only. The biochemical reagents are not designed for use in therapeutic or diagnostic applications. We are unable to ship to individuals. Please place all orders through an established firm or institution. Nothing disclosed is to be construed as a recommendation to use our products in violation of any patents. All research products are offered without warranty or guarantee, since the ultimate condition of use and the variability in material handling are beyond our control. |
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Colloidal Gold Conjugated Arachis hypogaea Lectin (Peanut) -PNA-, 10nm |
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| GP-2301-10 | EY Laboratories | 1 mL | Ask for price |
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Description: Colloidal Gold Conjugated Arachis hypogaea Lectin (Peanut) -PNA-, 10nm With the exception of Diagnostic Microbiology Products all biochemicals described are for research use only. The biochemical reagents are not designed for use in therapeutic or diagnostic applications. We are unable to ship to individuals. Please place all orders through an established firm or institution. Nothing disclosed is to be construed as a recommendation to use our products in violation of any patents. All research products are offered without warranty or guarantee, since the ultimate condition of use and the variability in material handling are beyond our control. |
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Colloidal Gold Conjugated Arachis hypogaea Lectin (Peanut) -PNA-, 15nm |
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| GP-2301-15 | EY Laboratories | 1 mL | Ask for price |
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Description: Colloidal Gold Conjugated Arachis hypogaea Lectin (Peanut) -PNA-, 15nm With the exception of Diagnostic Microbiology Products all biochemicals described are for research use only. The biochemical reagents are not designed for use in therapeutic or diagnostic applications. We are unable to ship to individuals. Please place all orders through an established firm or institution. Nothing disclosed is to be construed as a recommendation to use our products in violation of any patents. All research products are offered without warranty or guarantee, since the ultimate condition of use and the variability in material handling are beyond our control. |
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Colloidal Gold Conjugated Arachis hypogaea Lectin (Peanut) -PNA-, 20nm |
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| GP-2301-20 | EY Laboratories | 1 mL | Ask for price |
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Description: Colloidal Gold Conjugated Arachis hypogaea Lectin (Peanut) -PNA-, 20nm With the exception of Diagnostic Microbiology Products all biochemicals described are for research use only. The biochemical reagents are not designed for use in therapeutic or diagnostic applications. We are unable to ship to individuals. Please place all orders through an established firm or institution. Nothing disclosed is to be construed as a recommendation to use our products in violation of any patents. All research products are offered without warranty or guarantee, since the ultimate condition of use and the variability in material handling are beyond our control. |
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Colloidal Gold Conjugated Arachis hypogaea Lectin (Peanut) -PNA-, 30nm |
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| GP-2301-30 | EY Laboratories | 1 mL | Ask for price |
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Description: Colloidal Gold Conjugated Arachis hypogaea Lectin (Peanut) -PNA-, 30nm With the exception of Diagnostic Microbiology Products all biochemicals described are for research use only. The biochemical reagents are not designed for use in therapeutic or diagnostic applications. We are unable to ship to individuals. Please place all orders through an established firm or institution. Nothing disclosed is to be construed as a recommendation to use our products in violation of any patents. All research products are offered without warranty or guarantee, since the ultimate condition of use and the variability in material handling are beyond our control. |
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Colloidal Gold Conjugated Arachis hypogaea Lectin (Peanut) -PNA-, 40nm |
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| GP-2301-40 | EY Laboratories | 1 mL | Ask for price |
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Description: Colloidal Gold Conjugated Arachis hypogaea Lectin (Peanut) -PNA-, 40nm With the exception of Diagnostic Microbiology Products all biochemicals described are for research use only. The biochemical reagents are not designed for use in therapeutic or diagnostic applications. We are unable to ship to individuals. Please place all orders through an established firm or institution. Nothing disclosed is to be construed as a recommendation to use our products in violation of any patents. All research products are offered without warranty or guarantee, since the ultimate condition of use and the variability in material handling are beyond our control. |
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Arachis hypogaea lectin (PNA) |
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| 05-0116-10 | Medicago | 10 mg | EUR 139.2 |
Arachis hypogaea lectin (PNA |
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| 05-0116-1000 | Medicago | 1 g | Ask for price |
Arachis hypogaea lectin (PNA |
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| 05-0116-50 | Medicago | 50 mg | EUR 376.8 |
Arachis hypogaea Lectin (PNA) - Cy3 |
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| 21761088-1 | Bio-WORLD | - | EUR 189.93 |
Arachis hypogaea Lectin (PNA) - Cy3 |
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| 21761088-2 | Bio-WORLD | - | EUR 258.72 |
Arachis hypogaea Lectin (PNA) - Cy5 |
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| 21761089-1 | Bio-WORLD | - | EUR 189.93 |
Arachis hypogaea Lectin (PNA) - Cy5 |
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| 21761089-2 | Bio-WORLD | - | EUR 333.3 |
Arachis hypogaea Lectin (PNA) - Pure |
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| 21510000-1 | Bio-WORLD | - | EUR 104.8 |
Arachis hypogaea Lectin (PNA) - Pure |
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| 21510000-2 | Bio-WORLD | - | EUR 165.81 |
Arachis hypogaea Lectin (PNA) - Pure |
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| 21510000-3 | Bio-WORLD | - | EUR 432.26 |
Arachis hypogaea Lectin (PNA) - Ferritin |
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| 21510500-1 | Bio-WORLD | - | EUR 187.36 |
Arachis hypogaea Lectin (PNA) - HRP (Horseradish Peroxidase) |
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| 21510927-1 | Bio-WORLD | - | EUR 175.57 |
Arachis hypogaea Lectin (PNA) - Macrobeads |
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| 21511047-1 | Bio-WORLD | - | EUR 411.15 |